In 1999, the Boston-Based Adaptation in Nursing Research Society associates published their analysis of Roy adaptation model—based research. This earlier analysis supported the model's conceptual framework, its adaptive processes, and the influences that effect human responses. The purpose of this article is to describe more recent research within the context of the Roy adaptation model's structural framework, and ongoing developments that include expanded research programs, middle-range theory construction, and research that is related to the philosophic assumptions. An additional aim is to present an expanded worldview or an integrated paradigm that includes both sets of the Roy adaptation model's assumptions (scientific and philosophic), as well as a holistic-adaptation inquiry that could be used to derive Roy adaptation model-based nursing knowledge in future research investigations.